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Prescribing information for Wegovy and Ozempic emphasizes a gradual dose increase over the course of several months to improve how well your body tolerates the medication

Some experts note that better mental health often follows improvements in physical health, making it difficult to disentangle whether GLP-1 drugs have unique neurobiological effects or whether benefits arise from downstream consequences like weight loss and stabilized blood sugar

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GLP-1s help regulate glucose levels, which supports the adrenals and thyroid both vital for hormone balance in Hashimotos

GLP-1 and analogs increase glucose consumption in mature cells whereas they reduce it in progenitor cells and ADSCs, which can lead to decreased production of ATP and energy deficiency